Aim to assess the effects of Salvadoria persica and Nigella sativa combination in tooth socket healing after extraction that can be a novel remedy for tooth extraction socket. Methods Forty rabbits were included in this study, divided into two groups (control and experimental) with 20 rabbits. Upper right central incisors were extracted for all animals, the tooth sockets of the experimental group were dressed using an admix of Salvadoria persica and Nigella sativa immediately after irrigation with normal saline. In contrast, the extraction sockets of the control group were left without dressing. Biopsies were taken after euthanizing the animals at 1, 3, 7, and 14 days after treatment, histological examination was done for the samples at the given periods respectively. Results On day 1 post-treatment, histological examination of the experimental group sections showed less acute inflammatory reaction than the control group. This continued to be reduced until the seventh day. The amount of granulation tissue formation was more in the experimental group along the different periods of the study, while new bone formation was observed after 1 week as woven bone, increased after 2 weeks and appeared as woven and lamellar bone in both experimental and control groups. Conclusions A mixture of Salvadoria persica and Nigella sativa has an anti-inflammatory effect and accelerate bone healing by stimulating bone formation in the tooth extraction socket.

ABSTRACT Objectives: To evaluate the effectiveness of a mixture of Salvadoria persica and Nigella sativa in treating dry socket and use as a substitute for alvogyl. Patients and method: 52 randomly selected patients with dry socket confirmed clinically by diagnosis, divided into 2 groups, each group containing 26 patient group A treated by admix, and group B treated by alvogyl, clinical features were recorded on the first, second, and third days after treatment. Results: Visual Analog Scale of pain showed a high score on day one but decreased significantly at 2 and 3 days in both groups. But there were no significant differences in pain scores between the two groups on day 1, day 2, or day 3 separately. The two groups revealed identical mean rank scores of pain during the whole study period. Conclusions: A mixture of Salvadoria persica and Nigella sativa showed a significant analgesic and anti-inflammatory effect in the treatment of dry socket and can be used as a substitute for alvogyl.

RESUMEN Objetivos: Evaluar la eficacia de una mezcla de Salvadoria persica y Nigella sativa en el tratamiento de la alveolitis seca y su uso como sustituto del alvogyl. Pacientes y método: 52 pacientes seleccionados al azar con alveolitis seca confirmada clínicamente por diagnóstico, divididos en 2 grupos, cada grupo con 26 pacientes del grupo A tratado con admix y del grupo B tratado con alvogyl. Las características clínicas se registraron al primer, segundo y tercer día después del tratamiento. Resultados: La escala analógica visual del dolor mostró una puntuación alta el primer día, pero disminuyó significativamente a los 2 y 3 días en ambos grupos. No hubo diferencias significativas en las puntuaciones de dolor entre los 2 grupos los días 1, 2 y 3 por separado. Los dos grupos revelaron las mismas puntuaciones medias de rango de dolor durante todo el periodo de estudio. Conclusiones: Una mezcla de Salvadoria persica y Nigella sativa mostró un efecto analgésico y antinflamatorio significativo en el tratamiento de la alveolitis seca y puede utilizarse como sustituto del alvogyl.